Muscle Biology Lab

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The focus of the research program in the Muscle Biology Laboratory is to understand the mechanisms of muscle dysfunction associated with injury in normal and myopathic populations. Specific goals include the following: 1) elucidate the mechanisms of skeletal muscle strength loss and recovery associated with exercise-induced muscle injury in normal and myopathic populations; 2) seek to understand the molecular mechanisms of peri-infarct strength loss and cardiac remodeling after myocardial infarction; and 3) develop novel therapeutic interventions that prevent long-term muscle dysfunction and/or facilitate recovery of muscle function associated with these types of injury.
The Muscle Biology Laboratory at Georgia State University occupies approximately 400 sq ft in the Department of Kinesiology and Health in the Sports Arena Building. The laboratory is equipped to study skeletal muscle physiology, electrophysiology, biochemistry, histochemistry, and molecular and cellular biology.
In vivo muscle testing setup. Functions of this setup are to evaluate mouse anterior crural muscle function (torque-velocity and torque-frequency relationships) and to induce injury to the anterior crural muscle via the performance of eccentric contractions. Primary equipment includes an Aurora Scientific300B servomotor, Grass S11 stimulator, Grass SIU5 stimulus isolation unit, and P3 450MHz computer.
In vitro muscle testing setup. Functions of this setup are to evaluate mouse soleus and extensor digitorum longus muscle function (force-frequency, V max, Vo) and to induce injury to the muscles via the performance of eccentric contractions. Primary equipment includes an Aurora Scientific 300B servomotor, Grass S11 stimulator, Grass SIU5 stimulus isolation unit, and P3 450MHz computer.

  • Microscopes / photometry system
  • Cryostat
  • Ultra-cold freezer
  • Electrophoresis equipment (i.e., SDS-PAGE)
  • Western blotting equipment
  • Northern blotting equipment
  • Receptor binding assay equipment
  • Electrophysiological equipment
  • UV/VIS spectrophotometer
  • Fluorometer
  • Ca2+ mini-electrode (SR Ca2+ uptake and release rates)*
  • Analytical balances, centrifuges, autoclave, dishwasher, temperature controlled circulating water baths